ANEMIA : A quantitative deficiency of the hemoglobin, often accompanied by a reduced number of red blood cells and causing pallor, weakness, and breathlessness.
BIOLOGICS : Any substance, as a serum or vaccine, derived from animal products or other biological sources and used to treat or prevent disease.
B-cell Lymphoma : A type of non-Hodgkin lymphoma affecting B cells, whose principal function of is to make antibodies against soluble antigens. It develops more frequently in immunocomprimised individuals.
CANINE ATOPIC DERMATITIS : Dermatitis characterized by intense itching, occurring in individuals predisposed to developing certain hypersensitivity reactions. In dogs, this condition often is associated with intense itching, skin lesions and infections.
CANINE DILATED CARDIOMYOPATHY : Dilated cardiomyopathy is a condition in which the heart becomes weakened and enlarged, and cannot pump blood efficiently. The decreased heart function can affect the lungs, liver, and other body systems. In veterinary medicine, certain breeds are pre-disposed to this condition such as boxers and Doberman Pinschers.
CANINE OSTEOARTHRITIS : A joint disease caused by the breakdown and loss of the cartilage of one or more joints, often resulting in chronic inflammation and pain.
CONDITIONALLY APPROVED PRODUCTS : Products which have received a conditional license from the United States Department of Agriculture after demonstrating reasonable expectations of efficacy, safety, and purity.
Cutaneous T-cell Lymphoma (CTCL) : A class of non-Hodgkin's lymphoma, which is a type of cancer of the immune system. Unlike most non-Hodgkin's lymphomas (which are generally B-cell related), CTCL is caused by a mutation of T cells. The malignant T cells in the body are pushed to the surface of the skin in a biological process used to rid the body of offending material, causing various lesions to appear on the skin. There is no cure for CTCL currently.
CYTOKINE : Any of several non-antibody proteins, such as lymphokines, that are released by a cell population on contact with a specific antigen and act as intercellular mediators, as in the generation of an immune response.
EFFICACY : The ability of a drug or biologic to produce the desired therapeutic effect.
FELINE ASTHMA : Recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. It is usually either an allergic manifestation (allergic or extrinsic a.) or secondary to a chronic or recurrent condition.
FELINE IMMUNODEFICIENCY VIRUS (FIV) : Also known as Feline Aids, is a retrovirus that may result in severe immune suppression in cats. FIV can attack the immune system of cats, much like the human immunodeficiency virus (HIV) can attack the immune system of human beings.
FELINE LEUKEMIA VIRUS (FeLV): A retrovirus that may cause severe immune suppression, anemia, and result in increased risk of other infections. FeLV and FIV infections are two of the most common feline diseases worldwide.
GRANULOCYTOPENIA : Reduction in the number of granular leukocytes in the blood, such as neutrophils, eosinophils, and basophils.
HAART : Highly Active Anti-Retroviral Therapy. treatment of infection by retroviruses.
HIV : Human immunodeficiency virus (HIV) is a retrovirus that can lead to acquired immunodeficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections.
Hodgkin’s Lymphoma : A type of lymphoma characterized by the orderly spread of disease from one lymph node group to another and by the development of systemic symptoms with advanced disease. The cure rate is about 93%.
IMMUNE RESPONSE : An integrated bodily response to an antigen, especially one mediated by lymphocytes and involving recognition of antigens by specific antibodies or previously sensitized lymphocytes.
IMMUNE SUPPRESSION : Causing the immune system to become compromised or suppressed to the extent that an adequate response to pathogens, cancer, or inflammation is reduced.
Immunodeficiency virus : A virus that induces state in which the body’s immune system's ability to fight infectious disease is compromised or entirely absent.
IMMUNOMODULATOR : Typically a biological product which produces an immune response, usually to modify an immune response or stimulate an immune response.
ImSAIDS™ : A new class of anti-inflammatory peptides, called the Immune Selective Anti-Inflammatory Derivatives, which have been identified in the saliva, and produce a potent and rapid systemic anti-inflammatory effect. The mechanism of action is distinctly different from steroids or non-steroidal compounds.
INTERLEUKIN : Interleukins are a set of cytokines which act as cell signals and often help elicit and direct immune responses.
Kaposi’s Sarcoma : A tumor caused by Human herpesvirus 8 (HHV8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV). Kaposi’s sarcoma appears as nodules or blotches that may be red, purple, brown, or black, and are usually raised. Though they are typically found on the skin, but spread elsewhere is common, especially the mouth, gastrointestinal tract and respiratory tract.
LEUKEMIA : Any of various acute or chronic neoplastic diseases of the bone marrow in which unrestrained proliferation of white blood cells occurs and which is usually accompanied by anemia, impaired blood clotting, and enlargement of the lymph nodes, liver, and spleen.
LTCI : Lymphocyte T-Cell Immunomodulator, an immune modulating protein derived from a specialized thymic epithelial cell line.
LYOPHILIZED PRODUCT : A product which has been freeze dried, often to increase the shelf life of biologics.
LYMPHOCYTE : A white blood cell that plays a central role in immune responses to infections and cancer.
LYMPHOCYTE T-CELL IMMUNOMODULATOR : Lymphocyte T-Cell Immunomodulator, an immune modulating protein derived from a specialized thymic epithelial cell line.
LymphomA : A type of cancer that originates in lymphocytes. It account for about five percent of all cases of cancer in the United States.
LYMPHOPENIA : A reduction in the number of lymphocytes within the blood.
Mycosis fungoides : The most common form of cutaneous T-cell lymphoma. It generally affects the skin, but may progress internally over time. Typical visible symptoms include rashlike patches, tumors, or lesions. Itching (pruritus) is common, perhaps in 20% of patients, and is not universal.
PEPTIDES : A molecule that consists of amino acids, the basic building blocks of life.
Retroviruses : Enveloped viruses possessing an RNA genome, and replicate via a DNA intermediate. Retroviruses rely on the enzyme reverse transcriptase to perform the reverse transcription of its genome from RNA into DNA, which can then be integrated into the host's genome with an integrase enzyme. The virus then replicates as part of the cell's DNA.
SEPSIS : The presence of pathogenic organisms or their toxins in the blood or tissues.
TCR PEPTIDE VACCINES : An immune modulating vaccine that consists of a peptide derived from the T-Cell Receptor (TCR) of lymphocytes, which also engage the T-Cell Receptor to trigger a response.
TECHNOLOGY PLATFORMS : An industrial term used to indicate a single technology that can be developed into a number of products. For instance, the TCR Vaccine Platform is the same vaccine being developed for a variety of diseases.
TH-1/TH-2 BALANCE : A balance between T-helper (Th) cell subsets. Th1 helper cells stimulate cell mediated immunity while Th2 helper cells drive humoral immunity. In a number of veterinary diseases, such as atopic dermatitis, feline stomatitis, equine heaves, and certain bovine respiratory infections, this balance becomes offset and is thought to perpetuate the process. Restoring the Th1/Th2 balance is a new strategy for many companies to treat diseases.
T-cell LymphomA : (from: http://www.lymphomation.org/t-cell-types.htm) Cancers of t-cells, these are a family of cells that normally protect the body from disease, such as by eliminating our own cells that are infected with virus.
T-HELPER CELLS : A class of lymphocytes which direct and coordinate the immune response.
Thrombocytopenia : The presence of relatively few platelets in blood. Decreased platelet counts can be due to a many different disease processes.
ImSAIDs™ is a trademark of IMULAN BioTherapeutics, LLC